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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (2) Autor Santos-Filho,Norival A. (2) Cedro,Rafhaella C. A. (1) Costa,Tássia R. (1) Faccioli,Lúcia H. (1) Menaldo,Danilo L. (1) Sampaio,Suely V. (1) Santos,Claudia T. (1) Sartim,Marco A. (1) Zoccal,Karina F. (1) Mais... Palavra-chave Bothrops jararaca (1) Cytotoxicity (1) Inflammation (1) Myotoxin (1) Myotoxin inhibitor (1) Phospholipase A2 (1) Phospholipases A2 (1) Snake blood (1) Snake venom (1) ΑPLI (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2017 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Alpha-type phospholipase A2 inhibitors from snake blood J. Venom. Anim. Toxins incl. Trop. Dis. Santos-Filho,Norival A.; Santos,Claudia T.. Abstract It is of popular and scientific knowledge that toxins from snake venom (among them the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal blood. Venomous and nonvenomous snakes have PLA2 inhibitory proteins, called PLIs, in their blood serum. One hypothesis that could explain the presence of these PLIs in the serum of venomous snakes would be self-protection against the enzymes of their own venom, which eventually could reach the circulatory system. However, the presence of PLIs in non-venomous snakes suggests that their physiological role might not be restricted to protection against PLA2 toxins, but could be extended to other functions, as in the innate immune system and local... Tipo: Info:eu-repo/semantics/article Palavras-chave: Phospholipases A2; Myotoxin; Myotoxin inhibitor; ΑPLI; Snake blood. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100203 Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom J. Venom. Anim. Toxins incl. Trop. Dis. Cedro,Rafhaella C. A.; Menaldo,Danilo L.; Costa,Tássia R.; Zoccal,Karina F.; Sartim,Marco A.; Santos-Filho,Norival A.; Faccioli,Lúcia H.; Sampaio,Suely V.. Abstract Background: Snake venom phospholipases A2 (PLA2s) have been reported to induce myotoxic, neurotoxic, hemolytic, edematogenic, cytotoxic and proinflammatory effects. This work aimed at the isolation and functional characterization of a PLA2 isolated from Bothrops jararaca venom, named BJ-PLA2-I. Methods and Results: For its purification, three consecutive chromatographic steps were used (Sephacryl S-200, Source 15Q and Mono Q 5/50 GL). BJ-PLA2-I showed acidic characteristics, with pI~4.4 and molecular mass of 14. 2 kDa. Sequencing resulted in 60 amino acid residues that showed high similarity to other Bothrops PLA2s, including 100% identity with BJ-PLA2, an Asp49 PLA2 previously isolated from B. jararaca venom. Being an Asp49 PLA2, BJ-PLA2-I... Tipo: Info:eu-repo/semantics/article Palavras-chave: Snake venom; Bothrops jararaca; Phospholipase A2; Inflammation; Cytotoxicity. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100324 Registros recuperados: 2 Primeira ... 1 ... Última

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